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AJNR Am J Neuroradiol. 2009 Jan;30(1):132-5. doi: 10.3174/ajnr.A1247. Epub 2008 Aug 13.

Excitotoxicity in acute encephalopathy with biphasic seizures and late reduced diffusion.

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1
Department of Pediatrics, Kameda Medical Center, Kamogawa, Japan. jtaka@kameda.jp

Abstract

Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is a recently described clinicoradiologic syndrome. MR spectroscopy in 3 patients with AESD revealed decreased N-acetylaspartate (NAA) and elevated glutamine/glutamate complex (Glx) during the week of presentation. Afterward, Glx normalized, whereas NAA remained low in 2 patients with neurologic sequelae but nearly normalized in the third patient without neurologic sequelae. These findings support the hypothesis that excitotoxic neuronal damage plays an important role in the pathogenesis of AESD and suggest that MR spectroscopy might be predictive of outcome.

PMID:
18701579
DOI:
10.3174/ajnr.A1247
[Indexed for MEDLINE]
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