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Immunity. 2008 Aug 15;29(2):178-81. doi: 10.1016/j.immuni.2008.07.009.

Structural mechanism of RNA recognition by the RIG-I-like receptors.

Author information

1
Laboratory of Molecular Genetics, Institute for Virus Research, and Laboratory of Molecular Cell Biology, Graduate School of Biostudies, Kyoto University, Kyoto, 606-8507, Japan.

Abstract

Cytoplasmic nonself RNA, such as that generated by invading viruses, is recognized by a family of sensory molecules termed RIG-I-like Receptors (RLRs). Here, we discuss the mechanism of the RLRs' sensing of nonself RNA. Our findings define three functional domains of RLRs and provide insights into how RLRs function as a molecular switch through interactions with virus-specific RNA ligands.

PMID:
18701081
DOI:
10.1016/j.immuni.2008.07.009
[Indexed for MEDLINE]
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