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Nat Rev Mol Cell Biol. 2008 Sep;9(9):725-9. doi: 10.1038/nrm2466.

The promise of human induced pluripotent stem cells for research and therapy.

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Laboratory for Stem Cell Biology, Center for Developmental Biology, RIKEN, Kobe, Hyogo, Japan.


Induced pluripotent stem (iPS) cells are human somatic cells that have been reprogrammed to a pluripotent state. There are several hurdles to be overcome before iPS cells can be considered as a potential patient-specific cell therapy, and it will be crucial to characterize the developmental potential of human iPS cell lines. As a research tool, iPS-cell technology provides opportunities to study normal development and to understand reprogramming. iPS cells can have an immediate impact as models for human diseases, including cancer.

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