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Nat Rev Mol Cell Biol. 2008 Oct;9(10):810-5. doi: 10.1038/nrm2467. Epub 2008 Aug 13.

Transcription-independent functions of MYC: regulation of translation and DNA replication.

Author information

1
Department of Pharmacology, Dartmouth Medical School, Norris Cotton Cancer Center, One Medical Center Drive, Lebanon, New Hampshire 03756, USA.

Abstract

MYC is a potent oncogene that drives unrestrained cell growth and proliferation. Shortly after its discovery as an oncogene, the MYC protein was recognized as a sequence-specific transcription factor. Since that time, MYC oncogene research has focused on the mechanism of MYC-induced transcription and on the identification of MYC transcriptional target genes. Recently, MYC was shown to control protein expression through mRNA translation and to directly regulate DNA replication, thus initiating exciting new areas of oncogene research.

PMID:
18698328
PMCID:
PMC3880805
DOI:
10.1038/nrm2467
[Indexed for MEDLINE]
Free PMC Article

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