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Chemotherapy. 2008;54(4):328-30. doi: 10.1159/000151267. Epub 2008 Aug 12.

Enhancement of the antibiotic activity against a multiresistant Escherichia coli by Mentha arvensis L. and chlorpromazine.

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  • 1Laboratory of Research in Natural Products, Department of Physical and Biological Sciences, Center of Biological Sciences and Health, University of the Region of Cariri, Crato, Brazil. hdmcoutinho@gmail.com

Abstract

BACKGROUND:

This is the first report testing the antibiotic resistance-modifying activity of Mentha arvensis.

METHODS:

In this study an ethanol extract of M. arvensis L. and chlorpromazine were tested for their antimicrobial activity alone or in combination with conventional antibiotics against strains of Escherichia coli.

RESULTS:

The growth of two E. coli strains tested was not inhibited by the extract. The minimum inhibitory concentration and minimal bactericide concentration values were >or=1 mg/ml for both strains of E. coli used. A potentiating effect of this extract on gentamicin was demonstrated. Similarly, there was a potentiating effect of chlorpromazine on kanamycin, amikacin and tobramycin, indicating the involvement of an efflux system in the resistance to these aminoglycosides.

CONCLUSIONS:

It is therefore suggested that extracts from M. arvensis could be used as a source of plant-derived natural products with resistance-modifying activity, such as in the case of gentamicin, constituting a new weapon against bacterial resistance to antibiotics, as with chlorpromazine.

PMID:
18698137
DOI:
10.1159/000151267
[PubMed - indexed for MEDLINE]
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