Format

Send to

Choose Destination
See comment in PubMed Commons below
Physiology (Bethesda). 2008 Aug;23:205-11. doi: 10.1152/physiol.00008.2008.

The Na-K-ATPase and calcium-signaling microdomains.

Author information

1
Department of Physiology and Pharmacology, University of Toledo Health Science Campus, Toledo, Ohio, USA.

Abstract

The Na-K-ATPase is an energy-transducing ion pump that converts the free energy of ATP into transmembrane ion gradients. It also serves as a functional receptor for cardiotonic steroids such as ouabain and digoxin. Binding of ouabain to the Na-K-ATPase can activate calcium signaling in a cell-specific manner. The exquisite calcium modulation via the Na-K-ATPase is achieved by the ability of the pump to integrate signals from numerous protein and non-protein molecules, including ion transporters, channels, protein kinases/phosphatases, as well as cellular Na+. This review focuses on the unique properties of the Na-K-ATPase and its role in the formation of different calcium-signaling microdomains.

PMID:
18697994
PMCID:
PMC5375021
DOI:
10.1152/physiol.00008.2008
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon Icon for PubMed Central
    Loading ...
    Support Center