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J Clin Endocrinol Metab. 2008 Nov;93(11):4486-93. doi: 10.1210/jc.2007-2561. Epub 2008 Aug 12.

Association between interleukin-15 and obesity: interleukin-15 as a potential regulator of fat mass.

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Department of Infectious Diseases Rigshospitalet, Centre of Inflammation and Metabolism, University of Copenhagen, Section 7641, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.



IL-15 decreases lipid deposition in preadipocytes and decreases the mass of white adipose tissue in rats, indicating that IL-15 may take part in regulating this tissue. IL-15 is expressed in human skeletal muscle and skeletal muscle may be a source of plasma IL-15 and in this way regulate adipose tissue mass.


The relation between skeletal muscle IL-15 mRNA expression, plasma IL-15, and adipose tissue mass was studied in 199 humans divided into four groups on the basis of obesity and type 2 diabetes. Furthermore, using a DNA electrotransfer model, we assessed the effect of IL-15 overexpression in skeletal muscle of mice.


In humans, multiple regression analysis showed a negative association between plasma IL-15 and total fat mass (P<0.05), trunk fat mass (P<0.01), and percent fat mass (P<0.05), independent of type 2 diabetes. Negative associations were also found between muscle IL-15 mRNA and obesity parameters. IL-15 overexpression in skeletal muscle of mice reduced trunk fat mass but not sc fat mass.


Our results indicate that IL-15 may be a regulator of trunk fat mass.

[Indexed for MEDLINE]

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