Format

Send to

Choose Destination
See comment in PubMed Commons below
Neuroreport. 2008 Aug 27;19(13):1351-3. doi: 10.1097/WNR.0b013e32830c4698.

Is migraine a lateralization defect?

Author information

1
AV-Torppa Oy, Lohja bNational Public Health Institute, Helsinki, Finland.

Abstract

Migraine often co-occurs with patent foramen ovale (PFO), and some people have suggested surgical closure as an efficient treatment for migraine. Prospective studies, however, do not report radical effect of PFO surgery on migraine. Here, we examined the hypothesis that PFO and migraine may cooccur as two independent manifestations of lateralization defect during embryonic development. We measured the absolute displacement of a midline structure, the pineal gland, on brain scans of 39 migraineurs and 26 controls. We found a significant asymmetry of the pineal gland in migraineurs compared with controls. Our data suggest that migraine's circadian component and its association with PFO may be linked to a lateralization defect during embryogenesis, which could be a result from abnormal serotonin regulation.

PMID:
18695522
PMCID:
PMC2615685
DOI:
10.1097/WNR.0b013e32830c4698
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins Icon for PubMed Central
    Loading ...
    Support Center