Format

Send to

Choose Destination
Dev Cell. 2008 Aug;15(2):182-6. doi: 10.1016/j.devcel.2008.07.013.

The impact of gene location in the nucleus on transcriptional regulation.

Author information

1
Gene Regulation and Chromatin Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London W12ONN, UK. niall.dillon@csc.mrc.ac.uk <niall.dillon@csc.mrc.ac.uk>

Abstract

Localization of genes to different parts of the nucleus has the potential to promote activation or silencing of transcription. Current evidence suggests that these effects are mediated by specific molecular interactions between genes and nuclear structures rather than by partitioning of the nucleus into discrete compartments. A growing body of data identifies the nuclear envelope as a major organizer of location-specific interactions for both silent and active genes.

PMID:
18694558
DOI:
10.1016/j.devcel.2008.07.013
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center