Format

Send to

Choose Destination
Fertil Steril. 2009 Jul;92(1):157-62. doi: 10.1016/j.fertnstert.2008.05.029. Epub 2008 Aug 9.

Preimplantation aneuploidy testing for infertile patients of advanced maternal age: a randomized prospective trial.

Author information

1
Colorado Center for Reproductive Medicine, 10290 RidgeGate Circle, Lone Tree, CO 80124, USA. wschoolcraft@colocrm.com

Abstract

OBJECTIVE:

To assess the potential benefit of preimplantation aneuploidy testing on the outcome of in vitro fertilization (IVF) for women of advanced maternal age (AMA).

DESIGN:

Prospective randomized clinical trial.

SETTING:

Private IVF clinic.

PATIENT(S):

Sixty-two infertile AMA couples undergoing fertility treatment.

INTERVENTION(S):

Fluorescent in situ hybridization (FISH) for chromosomes X, Y, 13, 15, 16, 17, 18, 21, and 22.

MAIN OUTCOME MEASURE(S):

Preimplantation aneuploidy testing of biopsied blastomeres on day 3 of development.

RESULT(S):

Fertilization and blastocyst developmental rates were similar for the test and control groups: 80% versus 77.4% and 49% versus 48.2%, respectively. The average number of embryos transferred was comparable at 2.2 for the test group and 2.7 for the control group. Implantation rates were also equivalent across the two groups: 37.3% in the control group versus 36.5% in the test group. Nevertheless, the spontaneous abortion rate was observed to be lower for the test group: 25.9% versus 32.26% in the control group. This resulted in an observed increase in delivery rates for the test group: 78% versus 67.74% in the control group.

CONCLUSION(S):

Preimplantation aneuploidy testing does not appear to statistically significantly improve outcome parameters in infertile AMA patients; however, a trend toward a decrease in the spontaneous abortion rate with a subsequent higher delivery rate was observed.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center