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Mech Ageing Dev. 2008 Oct;129(10):611-3. doi: 10.1016/j.mad.2008.07.001. Epub 2008 Jul 23.

Quercetin-mediated longevity in Caenorhabditis elegans: is DAF-16 involved?

Author information

1
Humboldt-Universit├Ąt zu Berlin, Department of Biology, Arboretum, Spaethstr. 80/81, 12437 Berlin, Germany. nadines1976@aol.com

Abstract

The polyphenol quercetin has recently been found to extend lifespan and increase stress resistance in the nematode Caenorhabditis elegans. The forkhead transcription factor DAF-16 has previously been linked to these effects. However, by using a daf-16(mgDf50) mutant strain, we show that quercetin exposure leads to increased mean lifespans up to 15%. Furthermore, quercetin-treated daf-16(mgDf50) worms show an enhanced resistance to thermal and oxidative stress. Our data reveal that DAF-16 is not obligatorily required for quercetin-mediated longevity and stress resistance.

PMID:
18692520
DOI:
10.1016/j.mad.2008.07.001
[Indexed for MEDLINE]

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