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Cell. 2008 Aug 8;134(3):386-7. doi: 10.1016/j.cell.2008.07.029.

Otx2's incredible journey.

Author information

1
Department of Pathology and Cell Biology, Columbia University, College of Physicians and Surgeons, 630 W. 168(th) Street, 14-509 P&S Building, New York, NY 10032, USA. adr2111@columbia.edu

Abstract

A surprising new mechanism that regulates the plasticity of postnatal neurons is reported in this issue by Sugiyama et al. (2008). These authors show in mice that visual experience triggers cell-to-cell transfer of the homeoprotein Otx2 to cortical interneurons, where it promotes maturation of inhibitory neural circuitry and opens the critical period for plasticity in the visual cortex.

PMID:
18692461
DOI:
10.1016/j.cell.2008.07.029
[Indexed for MEDLINE]
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