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Semin Cell Dev Biol. 2008 Dec;19(6):494-501. doi: 10.1016/j.semcdb.2008.07.005. Epub 2008 Jul 25.

Regulation of flagellar length in Chlamydomonas.

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1
Department of Anatomy and Cell Biology, Oklahoma State University Center for Health Sciences, Tulsa, OK 74107, United States. nedra.wilson@okstate.edu

Abstract

Chlamydomonas reinhardtii has two apically localized flagella that are maintained at an equal and appropriate length. Assembly and maintenance of flagella requires a microtubule-based transport system known as intraflagellar transport (IFT). During IFT, proteins destined for incorporation into or removal from a flagellum are carried along doublet microtubules via IFT particles. Regulation of IFT activity therefore is pivotal in determining the length of a flagellum. Reviewed is our current understanding of the role of IFT and signal transduction pathways in the regulation of flagellar length.

PMID:
18692148
PMCID:
PMC2637527
DOI:
10.1016/j.semcdb.2008.07.005
[Indexed for MEDLINE]
Free PMC Article
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