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Neuroimage. 2008 Nov 15;43(3):447-57. doi: 10.1016/j.neuroimage.2008.07.009. Epub 2008 Jul 18.

Human brain white matter atlas: identification and assignment of common anatomical structures in superficial white matter.

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1
The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

Structural delineation and assignment are the fundamental steps in understanding the anatomy of the human brain. The white matter has been structurally defined in the past only at its core regions (deep white matter). However, the most peripheral white matter areas, which are interleaved between the cortex and the deep white matter, have lacked clear anatomical definitions and parcellations. We used axonal fiber alignment information from diffusion tensor imaging (DTI) to delineate the peripheral white matter, and investigated its relationship with the cortex and the deep white matter. Using DTI data from 81 healthy subjects, we identified nine common, blade-like anatomical regions, which were further parcellated into 21 subregions based on the cortical anatomy. Four short association fiber tracts connecting adjacent gyri (U-fibers) were also identified reproducibly among the healthy population. We anticipate that this atlas will be useful resource for atlas-based white matter anatomical studies.

PMID:
18692144
PMCID:
PMC2586008
DOI:
10.1016/j.neuroimage.2008.07.009
[Indexed for MEDLINE]
Free PMC Article

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