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Trends Microbiol. 2008 Sep;16(9):414-9. doi: 10.1016/j.tim.2008.06.001. Epub 2008 Aug 6.

Thermoacidophilic proteins for biofuel production.

Author information

1
Department of Energy Joint Genome Institute, Genomics Division, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA. mhess@lbl.gov

Abstract

Growing concerns about global climate change and energy dependence have led to an increased effort to reduce carbon emissions. A considerable reduction could be achieved by using biofuels from lignocellulosic biomass instead of fossil fuels. One major bottleneck of biofuel production from lignocellulose is the availability of efficient and inexpensive biocatalysts (i.e. alcohol dehydrogenases, cellulases and esterases) that are active and stable at high temperatures and low pH values. Although heterologous gene expression is used effectively to obtain recombinant proteins derived from mesophiles, the production of thermoacidophilic proteins is often unsuccessful. Some of the reasons for this failure and potential solutions for an increased production of novel extremophilic biocatalysts are discussed here.

PMID:
18691890
DOI:
10.1016/j.tim.2008.06.001
[Indexed for MEDLINE]

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