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Cancer Cell. 2008 Aug 12;14(2):105-7. doi: 10.1016/j.ccr.2008.07.011.

Even cancers want commitment: lineage identity and medulloblastoma formation.

Author information

1
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. ceberha@jhmi.edu

Abstract

In this issue of Cancer Cell, Yang et al. (2008) and Schüller et al. (2008) show that Hedgehog activation in either multipotent neural stem cells or developmentally restricted progenitors causes only medulloblastomas to form. These data suggest that some stem cell-derived tumors must commit to a specific lineage in order to grow.

PMID:
18691544
PMCID:
PMC4512647
DOI:
10.1016/j.ccr.2008.07.011
[Indexed for MEDLINE]
Free PMC Article

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