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Cancer Cell. 2008 Aug 12;14(2):103-5. doi: 10.1016/j.ccr.2008.07.010.

Beyond genetics: surprising determinants of cell fate in antitumor drugs.

Author information

1
Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093-0670, USA.

Abstract

In this issue of Cancer Cell, Gascoigne and Taylor (2008) report their findings of following 10,000 single cells incubated with three classes of antimitotic drugs, including paclitaxel (taxol). This extensive analysis reveals a previously unappreciated complexity in response to such drugs and demonstrates that it is more than genetics that determines cell life or death.

PMID:
18691543
PMCID:
PMC3132553
DOI:
10.1016/j.ccr.2008.07.010
[Indexed for MEDLINE]
Free PMC Article

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