Format

Send to

Choose Destination
See comment in PubMed Commons below
J Am Geriatr Soc. 2008 Sep;56(9):1704-9. doi: 10.1111/j.1532-5415.2008.01851.x. Epub 2008 Aug 4.

Time-course of cytokines during delirium in elderly patients with hip fractures.

Author information

1
Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Centre, Amsterdam, The Netherlands. b.c.vanmunster@amc.uva.nl

Erratum in

  • J Am Geriatr Soc. 2009 Jan;57(1):190.

Abstract

OBJECTIVES:

To compare the time-course of cytokine levels in patients with and without delirium and investigate differences in cytokine concentrations in delirium subtypes.

DESIGN:

Prospective cohort study.

SETTING:

Academic Medical Center, Amsterdam, 2005 through 2007.

PARTICIPANTS:

Patients aged 65 and older admitted for surgery after hip fracture.

MEASUREMENTS:

Experienced geriatric physicians used the Confusion Assessment Method to assess delirium and the Delirium Symptom Interview to assess delirium subtype. Tumor necrosis factor alpha (TNF-alpha) and interleukin (IL)-1beta, IL-6, IL-8, IL-10, and IL-12 were assayed in repeated serum samples using a cytometric bead array immunoassay.

RESULTS:

Of 221 admitted patients, 98 (mean age 84, 50 patients with delirium) were included, resulting in a total of 324 samples. Ninety-six percent of these samples had TNF-alpha, IL-1beta, and IL-10 levels below the reliable detection level. Differences between patients with and without delirium were observed in IL-6 (median 51 vs 36 pg/mL, P=.01) and IL-8 (median 15 vs 9 pg/mL, P=.03) levels. Changes over time in IL-6 and IL-8 levels in patients with delirium differed significantly from changes in levels in patients without delirium. The highest levels of IL-6 were present during delirium, and the highest levels of IL-8 were present before the development of delirium. Patients with the hyperactive (median 71 pg/mL) or mixed (median 73 pg/mL) subtype of delirium had higher IL-6 levels than patients with hypoactive delirium (median 16 pg/mL) (P=.02).

CONCLUSION:

IL-6 and IL-8 may contribute to the pathogenesis of postoperative delirium in elderly people. IL-6 may play a role in the hyperactive behavior of delirium.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center