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Curr Pharm Biotechnol. 2008 Aug;9(4):242-5.

Chemically-modified HA for therapy and regenerative medicine.

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Department of Medicinal Chemistry and Center for Therapeutic Biomaterials, The University of Utah, 419 Wakara Way, Suite 205, Salt Lake City, Utah 84108, USA.


Hyaluronan (HA) is a very useful polymer, but its properties sometimes need to be altered or enhanced by chemical modification for biomedical applications. A wide variety of HA derivatives are currently used for eye surgery, joint viscoelastic supplementation, and anti-adhesion films. The future promises to deliver new classes of HA-based reagents as well as new polymers that can be used in situ with living cells or within the body.

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