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Nature. 2008 Sep 4;455(7209):114-8. doi: 10.1038/nature07198.

Neurogenin 2 controls cortical neuron migration through regulation of Rnd2.

Author information

1
Division of Molecular Neurobiology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK.

Abstract

Motility is a universal property of newly generated neurons. How cell migration is coordinately regulated with other aspects of neuron production is not well understood. Here we show that the proneural protein neurogenin 2 (Neurog2), which controls neurogenesis in the embryonic cerebral cortex, directly induces the expression of the small GTP-binding protein Rnd2 (ref. 3) in newly generated mouse cortical neurons before they initiate migration. Rnd2 silencing leads to a defect in radial migration of cortical neurons similar to that observed when the Neurog2 gene is deleted. Remarkably, restoring Rnd2 expression in Neurog2-mutant neurons is sufficient to rescue their ability to migrate. Our results identify Rnd2 as a novel essential regulator of neuronal migration in the cerebral cortex and demonstrate that Rnd2 is a major effector of Neurog2 function in the promotion of migration. Thus, a proneural protein controls the complex cellular behaviour of cell migration through a remarkably direct pathway involving the transcriptional activation of a small GTP-binding protein.

PMID:
18690213
DOI:
10.1038/nature07198
[Indexed for MEDLINE]

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