This epidemiological study was conducted to evaluate the incidence of intestinal and urinary schistosomiasis in children from 6 to 14 years old in the district of Bandafassi of east Senegal. The stools of 505 children from 10 villages were examined. In addition water holes that might serve as biotopes for the intermediate host snails, i.e., Biomphalaria sp. and Bulinus sp., were located and tested. Findings demonstrated the existence of permanent foci of S. mansoni deep within the bush of the Bandafassi district. Sporadic distribution of praziquantel has been effective but not sufficient to eradicate permanent S. mansoni foci in test sites.