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Reprod Toxicol. 2008 Oct;26(2):156-63. doi: 10.1016/j.reprotox.2008.07.001. Epub 2008 Jul 17.

Effects of tartrazine on exploratory behavior in a three-generation toxicity study in mice.

Author information

1
Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health, Shinjuku-ku, Tokyo, Japan. t-tanaka@poohlover.net

Abstract

Tartrazine was given to mice in the diet at levels of 0 (control), 0.05%, 0.15%, and 0.45% from 5 weeks of age of the F(0) generation to 9 weeks of age of the F(2) generation, and selected reproductive and neurobehavioral parameters were measured. In the F(1) generation, the development of swimming direction at postnatal day (PND) 7 was accelerated significantly in male offspring in a dose-related manner. Surface righting at PND 7 was affected significantly in female offspring in dose-related manner. Several variables in exploratory behavior showed significant tendencies to be affected in the treatment groups in male offspring at 3 weeks of age. In the F(2) generation, the development of swimming direction at PND 7 was accelerated significantly in the high-dosed group in male offspring. Time taken of olfactory orientation at PND 14 was accelerated significantly in male offspring in a dose-related manner. Several variables in exploratory behavior showed significant tendencies to be affected in the treatment groups in male offspring at 3 weeks of age, and in males at 8 weeks of age. The dose levels of tartrazine in the present study produced a few adverse effects on neurobehavioral parameters throughout generations in mice.

PMID:
18687399
DOI:
10.1016/j.reprotox.2008.07.001
[Indexed for MEDLINE]

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