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Curr Opin Organ Transplant. 2008 Aug;13(4):344-9. doi: 10.1097/MOT.0b013e3283061126.

Targeting T-cell memory: where do we stand?

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1
Department of Immunology, Cleveland Clinic, Cleveland, Ohio 44195, USA. valujsa@ccf.org

Abstract

PURPOSE OF REVIEW:

The need to control donor-reactive T cell memory for successful organ transplantation is widely acknowledged. Alloreactive memory T cells are present in many human transplant recipients prior to transplantation and are less susceptible to the effects of currently used immunosuppression than naïve T cells. This review brings together recent advances in various fields of immunology that are potentially applicable for targeting memory T cells in sensitized transplant patients.

RECENT FINDINGS:

The topics of the discussion are evoked by the latest findings on immunobiology of memory T cells and include functional diversity of T-cell memory, characteristic features of memory T-cell homeostasis and signaling, costimulatory requirements of memory T cells and their susceptibility to regulation.

SUMMARY:

Despite apparent resistance of memory T cells to currently used therapies, recent findings suggest that recall responses by memory T cells can be controlled at many different levels. Use of this information may facilitate development of future tools managing T-cell memory in transplant settings.

PMID:
18685328
DOI:
10.1097/MOT.0b013e3283061126
[Indexed for MEDLINE]
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