Effects of methysergide in cats deprived of paradoxical sleep

Res Commun Chem Pathol Pharmacol. 1976 Nov;15(3):425-33.

Abstract

Methysergide maleate, a 5-hydroxytryptamine receptor blocker, was administered to cats deprived of paradoxical sleep for 48 hours. During the first six hours after methysergide, the latency to the first slow-wave sleep and paradoxical sleep episodes was increased and total sleep time decreased. The decrease in sleep reflects a loss of paradoxical sleep, while the amount of slow-wave sleep remained unchanged. Slow-wave sleep time, though unchanged in amount, was displaced to the end of the six-hour recording period. These results suggest that paradoxical sleep in cats is more sensitive to methysergide action than is slow-wave sleep.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Cats
  • Female
  • Male
  • Methysergide / analogs & derivatives
  • Methysergide / pharmacology*
  • Sleep / drug effects
  • Sleep Deprivation*
  • Sleep Stages / drug effects
  • Sleep, REM / drug effects
  • Sleep, REM / physiology*
  • Time Factors

Substances

  • Methysergide