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Curr Opin Organ Transplant. 2008 Apr;13(2):165-70. doi: 10.1097/MOT.0b013e3282f6391e.

Accommodation in organ transplantation.

Author information

1
Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA.

Abstract

PURPOSE OF REVIEW:

We review recent insights into the mechanisms and prevalence of accommodation. Accommodation refers to an acquired resistance of an organ graft to humoral injury and rejection.

RECENT FINDINGS:

Accommodation has been postulated to reflect changes in antibodies, control of complement and/or acquired resistance to injury by antibodies, complement or other factors. We discuss the importance of these mechanisms, highlighting new conclusions.

SUMMARY:

Accommodation may be a common, perhaps the most common, outcome of organ transplantation and, in some systems, a predictable outcome of organ xenotransplantation. Further understanding of how accommodation is induced and by what mechanisms it is manifest and maintained could have a profound impact on transplantation in general and perhaps on other fields.

PMID:
18685298
PMCID:
PMC2726737
DOI:
10.1097/MOT.0b013e3282f6391e
[Indexed for MEDLINE]
Free PMC Article

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