Format

Send to

Choose Destination
Osteoarthritis Cartilage. 2009 Feb;17(2):174-7. doi: 10.1016/j.joca.2008.06.004. Epub 2008 Aug 5.

Volumetric bone mineral density of the tibia is not increased in subjects with radiographic knee osteoarthritis.

Author information

1
MRC Epidemiology Resource Centre, Southampton, United Kingdom. maysamabdin@hotmail.com

Abstract

OBJECTIVES:

Radiographic osteoarthritis (ROA) has previously been shown to be associated with an increase in areal bone mineral density (BMD) as assessed by dual energy X-ray absorptiometry (DXA). Here we have assessed volumetric bone density, size and strength by peripheral quantitative computed tomography (pQCT) in a large population-based cohort study in which knee radiographs were available.

METHODS:

Two hundred and ninety-five men and 288 women from the MRC Hertfordshire Cohort Study underwent weight bearing extended knee X-rays and bone density measurement of the ipsi-lateral knee using pQCT.

RESULTS:

Increasing radiographic grade in men but not women was associated with an increase in tibial total area at 38% site and cortical area at 14% site, but not with volumetric BMD. The tibial fracture loads as well as tibial polar strength strain index at 38% site were also increased. There were no significant associations of tibia bone area, BMD or strength with radiographic grade in women.

CONCLUSION:

ROA is not associated with an increase in volumetric BMD as assessed by pQCT. It is, however, associated with a significant increase in bone area and strength, indicating that the association between ROA and areal BMD is mediated through bone size rather than volumetric BMD.

PMID:
18684648
DOI:
10.1016/j.joca.2008.06.004
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center