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Schizophr Res. 2008 Sep;104(1-3):79-84. doi: 10.1016/j.schres.2008.06.008. Epub 2008 Aug 5.

Smoking status as a potential confound in the BOLD response of patients with schizophrenia.

Author information

1
The Mind Research Network, Pete & Nancy Domenici Hall, 1101 Yale Blvd. NE, Albuquerque, NM 87131, United States. lleyba@salud.unm.edu

Abstract

BACKGROUND:

Functional magnetic resonance imaging (FMRI) studies comparing schizophrenia patients and controls may have been confounded by the vascular effects of heavier long-term cigarette use in patients.

METHODS:

The blood oxygen level dependent (BOLD) response to a simple sensorimotor task was compared between schizophrenia patient with a smoking history (mean 17 pack years) and carefully matched patient non-smokers and control non-smokers.

RESULTS:

Group differences in activation magnitude and spatial extent were non-significant.

CONCLUSIONS:

Typical smoking histories in schizophrenia patients do not significantly confound FMRI results in simple sensorimotor tasks when patient demographics are carefully controlled.

PMID:
18684594
PMCID:
PMC2577169
DOI:
10.1016/j.schres.2008.06.008
[Indexed for MEDLINE]
Free PMC Article

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