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Nano Lett. 2008 Sep;8(9):2800-5. doi: 10.1021/nl801362a. Epub 2008 Aug 7.

Noninvasive Raman spectroscopy in living mice for evaluation of tumor targeting with carbon nanotubes.

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1
Molecular Imaging Program at Stanford, Department of Radiology, Stanford University, 1201 Welch Road, Stanford, California 94305-5484, USA.

Abstract

An optimized noninvasive Raman microscope was used to evaluate tumor targeting and localization of single walled carbon nanotubes (SWNTs) in mice. Raman images were acquired in two groups of tumor-bearing mice. The control group received plain-SWNTs, whereas the experimental group received tumor targeting RGD-SWNTs intravenously. Raman imaging commenced over the next 72 h and revealed increased accumulation of RGD-SWNTs in tumor ( p < 0.05) as opposed to plain-SWNTs. These results support the development of a new preclinical Raman imager.

PMID:
18683988
PMCID:
PMC2910584
DOI:
10.1021/nl801362a
[Indexed for MEDLINE]
Free PMC Article
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