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Curr Opin Mol Ther. 2008 Aug;10(4):407-17.

IMVAMUNE, an attenuated modified vaccinia Ankara virus vaccine for smallpox infection.

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MedImmune Inc, 297 N Bernardo Ave, Mountain View, CA 94043, USA.


Bavarian Nordic is developing IMVAMUNE, which is based on a live attenuated modified vaccinia Ankara virus, for the potential prevention of smallpox infection, particularly in those patients contraindicated to traditional smallpox vaccines, such as the immunocompromised and those with eczema or dermatitis. In phase I and II clinical trials, IMVAMUNE was highly immunogenic and safe with no unexpected side effects or serious adverse effects reported in either healthy volunteers, those immunocompromised by HIV infection or in volunteers with atopic dermatitis. Additional phase II trials were ongoing in these groups at the time of publication and phase III trials were planned for 2009.

[Indexed for MEDLINE]

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