Format

Send to

Choose Destination
See comment in PubMed Commons below
Support Care Cancer. 2008 Oct;16(10):1105-15. doi: 10.1007/s00520-008-0487-0. Epub 2008 Aug 6.

Metastatic bone pain: treatment options with an emphasis on bisphosphonates.

Author information

  • 1Medical Oncology, Kantonsspital Graub√ľnden, Loestrasse 170, Chur, 7000, Switzerland. roger.vonmoos@ksgr.ch

Abstract

INTRODUCTION:

One of the key targets for metastatic cancer cells is the skeleton. Once metastatic cells are established within the bone matrix, skeletal integrity becomes increasingly compromised. Bone lesions lead to various complications, including bone pain, fractures and spinal cord compression.

MECHANISMS OF BONE PAIN:

Bone pain is debilitating and affects quality of life of the patient. In addition, it increases the use of health care resources. Many patients with metastatic bone disease experience substantial bone pain despite state-of-the-art systemic analgesic treatment. Incident pain is the predominant pain syndrome.

TREATMENT OPTIONS FOR BONE PAIN:

Typically, this syndrome requires moderate baseline analgesia with increased on-demand doses. Other techniques for treating bone pain, including radiation therapy, neuraxial application of analgesics, nerve blocks and local stabilisation procedures, should be considered. In addition, therapy with bisphosphonates targeting bone-specific pain is an important strategy. This review discusses the various management options for bone pain arising from metastatic bone disease.

PMID:
18682990
DOI:
10.1007/s00520-008-0487-0
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center