Format

Send to

Choose Destination
Epigenetics. 2008 Jul-Aug;3(4):193-8. Epub 2008 Jul 26.

A review of dietary factors and its influence on DNA methylation in colorectal carcinogenesis.

Author information

1
Human Nutrition Research Centre, School of Clinical Medical Sciences, Newcastle University, Newcastle, UK. r.p.arasaradnam@ncl.ac.uk

Abstract

Colorectal cancer (CRC) is the most common cancer in non-smokers posing a significant health burden in the UK. Observational studies lend support to the impact of environmental factors especially diet on colorectal carcinogenesis. Significant advances have been made in understanding the biology of CRC carcinogenesis in particular epigenetic modifications such as DNA methylation. DNA methylation is thought to occur at least as commonly as inactivation of tumor suppressor genes. In fact compared with other human cancers, promoter gene methylation occurs most commonly within the gastrointestinal tract. Emerging data suggest the direct influence of certain micronutrients for example folic acid, selenium as well as interaction with toxins such as alcohol on DNA methylation. Such interactions are likely to have a mechanistic impact on CRC carcinogenesis through the methylation pathway but also, may offer possible therapeutic potential as nutraceuticals.

PMID:
18682688
DOI:
10.4161/epi.3.4.6508
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center