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Nat Rev Microbiol. 2008 Sep;6(9):657-66. doi: 10.1038/nrmicro1955.

Revisiting the host as a growth medium.

Author information

1
Section of Molecular Genetics and Microbiology, The University of Texas at Austin, Austin, Texas 78712, USA.

Abstract

The ability of the human body to play host to bacterial pathogens has been studied for more than 200 years. Successful pathogenesis relies on the ability to acquire the nutrients that are necessary for growth and survival, yet relatively little is understood about the in vivo physiology and metabolism of most human pathogens. This Review discusses how in vivo carbon sources can affect disease and highlights the concept that carbon metabolic pathways provide viable targets for antibiotic development.

PMID:
18679171
PMCID:
PMC3115587
DOI:
10.1038/nrmicro1955
[Indexed for MEDLINE]
Free PMC Article

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