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Nucleic Acids Res. 2008 Sep;36(16):5123-38. doi: 10.1093/nar/gkn493. Epub 2008 Aug 1.

The triple helix: 50 years later, the outcome.

Author information

1
LCMBA CNRS UMR6001, University of Nice-Sophia Antipolis, Parc Valrose, 06108 NICE Cedex 2, France.

Abstract

Triplex-forming oligonucleotides constitute an interesting DNA sequence-specific tool that can be used to target cleaving or cross-linking agents, transcription factors or nucleases to a chosen site on the DNA. They are not only used as biotechnological tools but also to induce modifications on DNA with the aim to control gene expression, such as by site-directed mutagenesis or DNA recombination. Here, we report the state of art of the triplex-based anti-gene strategy 50 years after the discovery of such a structure, and we show the importance of the actual applications and the main challenges that we still have ahead of us.

PMID:
18676453
PMCID:
PMC2532714
DOI:
10.1093/nar/gkn493
[Indexed for MEDLINE]
Free PMC Article

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