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Biochim Biophys Acta. 2009 Jan;1789(1):17-25. doi: 10.1016/j.bbagrm.2008.07.002. Epub 2008 Jul 15.

Chromatin loops in gene regulation.

Author information

1
Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Abstract

The control of gene expression involves regulatory elements that can be very far from the genes they control. Several recent technological advances have allowed the direct detection of chromatin loops that juxtapose distant genomic sites in the nucleus. Here we review recent studies from various model organisms that have provided new insights into the functions of chromatin loops and the mechanisms that form them. We discuss the widespread impact of chromatin loops on gene activation, repression, genomic imprinting and the function of enhancers and insulators.

PMID:
18675948
PMCID:
PMC2638769
DOI:
10.1016/j.bbagrm.2008.07.002
[Indexed for MEDLINE]
Free PMC Article

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