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Ophthalmology. 2008 Aug;115(8):1366-71, 1371.e1. doi: 10.1016/j.ophtha.2007.12.004.

Optical coherence tomography measurements and analysis methods in optical coherence tomography studies of diabetic macular edema.

Collaborators (259)

Safar A, Kim NM, Walsh AC, Sadda S, Schwartz SD, Gonzales CR, Chen S, Daniels SA, Leong CJ, Ray SK, Ting TD, Verne AZ, Kuppermann BD, Tu ES, Fong D, Pince KJ, Pieramici DJ, Castellarin AA, Nasir MA, Jumper JM, Fu AD, Johnson RN, McDonald HR, Fan JT, Rauser ME, Suthar MB, Chan CK, Lin SG, Nuthi AS, Salib DM, Novack RL, Boyer DS, Hopkins JJ, Rahhal FM, Tabandeh H, Teasley LA, Lansing M, Braverman JM, Larrison WI, Mathura JR Jr, Jones BE, Chen M, Niffenegger JH, Wing G, Ghuman AT, Grodin RW, Raskauskas PA, Walker JP, Glatzer RJ, Dhalla MS, Thompson WS, Perez Ortiz DJ, Friedman SM, Plous OZ, Richmond PP, Barnes CD, Okun NJ, Olson JC, Shaikh SA, Tolentino M, Berger A, Hamilton RS, Moon SJ, Chalam KV, Grover S, Gupta SK, Marcus DM, Singh H, Drouilhet JH, Kokame GT, Scott MH, MacCumber MW, Lyon AT, Gill MK, Mirza RG, Pollack JS, Civantos JM, Flood TP, MacCumber MW, Lim JI, Blair NP, Blair MP, Ulanski LJ 2nd, Maturi RK, Ciulla T, Hrisomalos NF, Minturn JT, Maturi RK, Lazarus HS, Baker CW, Stone TW, Isernhagen RD, Kitchens JW, Wood WJ, Gitter KA, Willson RL, Sharuk GS, Aiello LP, Arrigg PG, Murtha TJ, Schlossman DK, Shah ST, Sun JK, Topping TM, Cleary TA, Heier JS, Krzystolik MG, Phillips WB 2nd, Berinstein D, Garfinkel R, Kaplan G, Von Fricken MA, Bressler S, Bressler NM, Do DV, Finkelstein D, Solomon SD, Sung JU, Zimmer-Galler I, Elman MJ, Benner JD, Butler JW, Hoffert D, Flynn TE, Edwards PA, Abrams GW, Mahmoud T, Trese MT, Ruby AJ, Aaberg TM, Margherio AR, Raphaelian PV, Garber FW, Glazer LC, Zheutlin JD, Sarrafizadeh R, Noffke AS, Klesert TR, Bhavsar A, Emerson GG, Feman SS, Akduman L, Apte RS, Blinder KJ, Engelbrecht NE, Rao PK, Batlle IR, Greven CM, Kurup SK, Slusher MM, Browning D, Antoszyk AN, Brown JC, Ridley ME, Hartnett ME, Garg S, Houghton OM, Meredith TA, Chace R, Ie D, Lipkowitz JL, Beer PM, Falk N, Hampton GR, Rutledge BK, Spalding SC, Torrisi PF, Gentile RC, Ponce EA, DiLoreto DA Jr, Chung MM, Cooney MJ, Sorenson JA, Singerman LJ, Coney JM, Miller DG, Novak MA, Huang SS, Tang J, Davidorf FH, Chang S, Christoforidis JB, Kingsley RM, Leonard RE 2nd, Lauer AK, Flaxel CJ, Francis PJ, Hwang TS, Peters MA, Dreyer RF, Handelman IL, Lee MS, Lemley CA, Ma C, Gardner TW, Neely KA, Scott IU, Brucker AJ, Kaufman SR, Estafanous MF, Wenz RE, Smith CW, Woodcome HA Jr, Wells JA 3rd, Clark WL, Gross JG, Fishburne BC, Magee MA, Abraham P, Googe J Jr, Anderson NG, McMillan TA, Perkins SL, Recchia FM, Agarwal A, Sternberg P Jr, Cummings HL, Couch DA, Gunn JM, Davis GH, Berger BB, Fish GE, Wang RC, Shami M, Smith SR, Lambert HM, Diaz-Rohena R, Khawly JA, Willis AW, Callanan DG, Solley WA, Brown DM, Benz MS, Chen E, Fish RH, Kim RY, Wong TP, Garcia CA, McCrary J, Pons ME, Patel SS, Lee SY, Gonzalez VH, Patel NR, Su YT, Goodart RA, Faber DW, Kinyoun JL, Kim JE, Connor TB Jr, Han DP, Stepien KE, Weinberg DV, Wirostko WJ, Gottlieb J, Altaweel MM, Blodi BA, Ip MS, Nork TM.

Author information

1
Jaeb Center for Health Research, 15310 Amberly Drive, Suite 350, Tampa, FL 33647, USA. drcrnetX1@jaeb.org

Abstract

OBJECTIVE:

To evaluate optical coherence tomography (OCT) measurements and methods of analysis of OCT data in studies of diabetic macular edema (DME).

DESIGN:

Associations of pairs of OCT variables and results of 3 analysis methods using data from 2 studies of DME.

PARTICIPANTS:

Two hundred sixty-three subjects from a study of modified Early Treatment of Diabetic Retinopathy Study (mETDRS) versus modified macular grid (MMG) photocoagulation for DME and 96 subjects from a study of diurnal variation of DME.

METHODS:

Correlations were calculated for pairs of OCT variables at baseline and for changes in the variables over time. Distribution of OCT measurement changes, predictive factors for OCT measurement changes, and treatment group outcomes were compared when 3 measures of change in macular thickness were analyzed: absolute change in retinal thickness, relative change in retinal thickness, and relative change in retinal thickening.

MAIN OUTCOME MEASURES:

Concordance of results using different OCT variables and analysis methods.

RESULTS:

Center point thickness correlated highly with central subfield mean thickness (CSMT) at baseline (0.98-0.99). The distributions of changes in CSMT were approximately normally distributed for absolute change in retinal thickness and relative change in retinal thickness, but not for relative change in retinal thickening. Macular thinning in the mETDRS group was significantly greater than in the MMG group when absolute change in retinal thickness was used, but not when relative change in thickness and relative change in thickening were used. Relative change in macular thickening provides unstable data in eyes with mild degrees of baseline thickening, unlike the situation with absolute or relative change in retinal thickness.

CONCLUSIONS:

Central subfield mean thickness is the preferred OCT measurement for the central macula because of its higher reproducibility and correlation with other measurements of the central macula. Total macular volume may be preferred when the central macula is less important. Absolute change in retinal thickness is the preferred analysis method in studies involving eyes with mild macular thickening. Relative change in thickening may be preferable when retinal thickening is more severe.

PMID:
18675696
PMCID:
PMC2748270
DOI:
10.1016/j.ophtha.2007.12.004
[Indexed for MEDLINE]
Free PMC Article
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