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Trends Parasitol. 2008 Sep;24(9):392-5. doi: 10.1016/j.pt.2008.05.007. Epub 2008 Jul 31.

Malaria vaccines: immunity, models and monoclonal antibodies.

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  • 1Centre for Medical Parasitology at the Department for International Health, Immunology, and Microbiology (ISIM), University of Copenhagen, 1014 Copenhagen K, Denmark. lhcmp@rh.dk

Abstract

Although experts in the field have agreed on the malaria vaccine technology roadmap that should be followed (http://www.malariavaccineroadmap.net/), the path towards an effective malaria vaccine remains littered with intellectual and practical pot-holes. The animal models that are currently available are problematic, and current understanding of the exact mechanisms and targets of protective immune responses is incomplete. However, recent technological advances might help overcome some of these hurdles.

PMID:
18675589
DOI:
10.1016/j.pt.2008.05.007
[PubMed - indexed for MEDLINE]
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