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Trends Neurosci. 2008 Sep;31(9):464-8. doi: 10.1016/j.tins.2008.06.006. Epub 2008 Jul 31.

The HPA axis in major depression: classical theories and new developments.

Author information

1
Institute of Psychiatry, King's College London, Division of Psychological Medicine and Psychiatry, Centre for the Cellular Basis of Behaviour, London, UK.

Abstract

Studies over the last 40 years have demonstrated that hyperactivity of the hypothalamic-pituitary-adrenal axis is one of the most consistent biological findings in major depression psychiatry, but the mechanisms underlying this abnormality are still unclear.

PMID:
18675469
DOI:
10.1016/j.tins.2008.06.006
[Indexed for MEDLINE]

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