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Fertil Steril. 2009 May;91(5):1686-91. doi: 10.1016/j.fertnstert.2008.02.121. Epub 2008 Jul 30.

Reduced expression of biomarkers associated with the implantation window in women with endometriosis.

Author information

1
Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.

Abstract

OBJECTIVE:

To evaluate the expression of biomarkers of implantation, glycodelin A (GdA), osteopontin (OPN), lysophosphatidic acid receptor 3 (LPA3), and HOXA10, in eutopic endometrium of women with and without endometriosis.

DESIGN:

Prospective observational study.

SETTING:

Clinical research center.

PATIENT(S):

Twenty-four women with endometriosis and 23 healthy volunteers of similar age.

INTERVENTION(S):

Secretory phase endometrial biopsy.

MAIN OUTCOME MEASURE(S):

Expression of immunohistochemical staining intensity and localization of GdA, OPN, LPA3, and HOXA10 in eutopic endometrium.

RESULT(S):

Endometrial GdA expression was significantly reduced in patients after cycle day 22. The endometrium from women with endometriosis also showed decreased expression of OPN in the late secretory phase and LPA3 and HOXA10 expression in the midsecretory and late secretory phases.

CONCLUSION(S):

The decreased expression of these four biomarkers of implantation may indicate impaired endometrial receptivity in patients with endometriosis, providing one explanation for the subfertility observed even in women with few pelvic implants. Because many of these markers are P dependent, these findings suggest the possibility of reduced endometrial P action in this population.

PMID:
18672236
PMCID:
PMC2697117
DOI:
10.1016/j.fertnstert.2008.02.121
[Indexed for MEDLINE]
Free PMC Article

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