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Microbes Infect. 2008 Jul;10(9):960-7. doi: 10.1016/j.micinf.2008.07.006. Epub 2008 Jul 10.

Role of HIV-1 Vpu protein for virus spread and pathogenesis.

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1
Department of Virology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima-shi, Tokushima, 770-8503, Japan.

Abstract

Vpu is an accessory viral protein almost unique to HIV-1 among primate immunodeficiency viruses, and has two major functions: degradation of the CD4 molecule in endoplasmic reticulum and enhancement of virion release from cells. Recent identification of a novel host restriction factor, tetherin, as a Vpu-antagonist suggests that Vpu contributes to virus spread by facilitating progeny virion production. This review focuses on the two distinct functions of Vpu and summarizes current knowledge on its virological role in the HIV-1 life cycle.

PMID:
18672082
DOI:
10.1016/j.micinf.2008.07.006
[Indexed for MEDLINE]
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