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Fitoterapia. 2008 Dec;79(7-8):539-43. doi: 10.1016/j.fitote.2008.05.008. Epub 2008 Jul 10.

Hypoglycemic effect of Mucuna pruriens seed extract on normal and streptozotocin-diabetic rats.

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Department of Biotechnology, Bishop Heber College (Autonomous), Tiruchirappalli, Tamil Nadu 620 017, India.


The hypoglycemic effect of the aqueous extract of the seeds of Mucuna pruriens was investigated in normal, glucose load conditions and streptozotocin (STZ)-induced diabetic rats. In normal rats, the aqueous extract of the seeds of Mucuna pririens (100 and 200 mg/kg body weight) significantly (P<0.001) reduced the blood glucose levels after an oral glucose load from 127.5+/-3.2 to 75.6+/-4.8 mg% 2 h after oral administration of seed extract. It also significantly lowered the blood glucose in STZ diabetic rats from 240.5+/-7.2 to 90.6+/-5.6 mg% after 21 days of daily oral administration of the extract (P<0.001). Thus, this study shows that M. pruriens has an anti-hyperglycemic action and it could be a source of hypoglycemic compounds.

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