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Fitoterapia. 2008 Dec;79(7-8):539-43. doi: 10.1016/j.fitote.2008.05.008. Epub 2008 Jul 10.

Hypoglycemic effect of Mucuna pruriens seed extract on normal and streptozotocin-diabetic rats.

Author information

1
Department of Biotechnology, Bishop Heber College (Autonomous), Tiruchirappalli, Tamil Nadu 620 017, India. anushaparthiban@gmail.com

Abstract

The hypoglycemic effect of the aqueous extract of the seeds of Mucuna pruriens was investigated in normal, glucose load conditions and streptozotocin (STZ)-induced diabetic rats. In normal rats, the aqueous extract of the seeds of Mucuna pririens (100 and 200 mg/kg body weight) significantly (P<0.001) reduced the blood glucose levels after an oral glucose load from 127.5+/-3.2 to 75.6+/-4.8 mg% 2 h after oral administration of seed extract. It also significantly lowered the blood glucose in STZ diabetic rats from 240.5+/-7.2 to 90.6+/-5.6 mg% after 21 days of daily oral administration of the extract (P<0.001). Thus, this study shows that M. pruriens has an anti-hyperglycemic action and it could be a source of hypoglycemic compounds.

PMID:
18672037
DOI:
10.1016/j.fitote.2008.05.008
[Indexed for MEDLINE]

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