Format

Send to

Choose Destination
J Comp Neurol. 2008 Oct 10;510(5):475-83. doi: 10.1002/cne.21800.

Sensory-dependent asymmetry for a urine-responsive olfactory bulb glomerulus.

Author information

1
Department of Cell and Developmental Biology, Neuroscience Program and Rocky Mountain Taste and Smell Center, University of Colorado Denver, School of Medicine, Aurora, Colorado 80045, USA.

Abstract

An unusual property of the olfactory system is that sensory input at the level of the first synapse in the olfactory bulb takes place at two mirror-image glomerular maps that appear identical across the axis of symmetry. It is puzzling how two identical odor maps would contribute to sensory function. The functional units in these maps are the glomeruli, ovoid neuropil structures formed by axons from olfactory sensory neurons expressing the same olfactory receptor. Here we find that the genetically identified P2 glomeruli are asymmetric across the axis of symmetry in terms of responsiveness to urine volatiles and neuroanatomical structure. Furthermore, P2 asymmetry is modified by sensory deprivation and abolished by decreased BDNF levels. Thus, while mirror odor maps show symmetry at the macroscopic level in maps encompassing the entire surface of the olfactory bulb, they display asymmetry at the level of the single glomerulus.

PMID:
18671299
PMCID:
PMC2542582
DOI:
10.1002/cne.21800
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center