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Free Radic Res. 2008 Aug;42(8):689-706. doi: 10.1080/10715760802317663.

Glutathione and apoptosis.

Author information

1
Department of Molecular & Cellular Physiology, Louisiana University Health Sciences Center, Shreveport, Louisiana, USA.

Abstract

Apoptosis or programmed cell death represents a physiologically conserved mechanism of cell death that is pivotal in normal development and tissue homeostasis in all organisms. As a key modulator of cell functions, the most abundant non-protein thiol, glutathione (GSH), has important roles in cellular defense against oxidant aggression, redox regulation of proteins thiols and maintaining redox homeostasis that is critical for proper function of cellular processes, including apoptosis. Thus, a shift in the cellular GSH-to-GSSG redox balance in favour of the oxidized species, GSSG, constitutes an important signal that could decide the fate of a cell. The current review will focus on three main areas: (1) general description of cellular apoptotic pathways, (2) cellular compartmentation of GSH and the contribution of mitochondrial GSH and redox proteins to apoptotic signalling and (3) role of redox mechanisms in the initiation and execution phases of apoptosis.

PMID:
18671159
PMCID:
PMC3171829
DOI:
10.1080/10715760802317663
[Indexed for MEDLINE]
Free PMC Article

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