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J Neurophysiol. 2008 Oct;100(4):2430-40. doi: 10.1152/jn.90687.2008. Epub 2008 Jul 30.

Large-scale chronically implantable precision motorized microdrive array for freely behaving animals.

Author information

1
Department of Brain and Cognitive Sciences, RIKEN-MIT Neuroscience Research Center, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. yamajun@MIT.edu

Abstract

Multiple single-unit recording has become one of the most powerful in vivo electro-physiological techniques for studying neural circuits. The demand has been increasing for small and lightweight chronic recording devices that allow fine adjustments to be made over large numbers of electrodes across multiple brain regions. To achieve this, we developed precision motorized microdrive arrays that use a novel motor multiplexing headstage to dramatically reduce wiring while preserving precision of the microdrive control. Versions of the microdrive array were chronically implanted on both rats (21 microdrives) and mice (7 microdrives), and relatively long-term recordings were taken.

PMID:
18667539
PMCID:
PMC2576215
DOI:
10.1152/jn.90687.2008
[Indexed for MEDLINE]
Free PMC Article

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