Format

Send to

Choose Destination
Neuron. 2008 Jul 31;59(2):190-4. doi: 10.1016/j.neuron.2008.07.013.

Linking calcium to Abeta and Alzheimer's disease.

Author information

1
Department of Neurobiology and Behavior and Institute for Brain Aging and Dementia, University of California, Irvine, Irvine, CA 92697-4545, USA. kngreen@uci.edu

Abstract

Recent developments point to a critical role for calcium dysregulation in the pathogenesis of Alzheimer's disease. A novel calcium-conducting channel called CALHM1 is genetically linked to the disorder and modulates Abeta production. Calcium homeostasis has also been shown to be perturbed in dendritic spines adjacent to amyloid plaques. Finally, new studies have elucidated the role by which presenilins modulate calcium signaling, including effects on SERCA2b and gating of the IP(3) receptor, and lead to Abeta production.

PMID:
18667147
DOI:
10.1016/j.neuron.2008.07.013
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center