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Nutr Rev. 2008 Jul;66(7):406-14. doi: 10.1111/j.1753-4887.2008.00050.x.

Genetic polymorphisms as determinants for disease-preventive effects of vitamin E.

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  • 1Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.


Polymorphisms in genes involved in vitamin E uptake, distribution, metabolism, and molecular action may be important determinants for the protective effects of vitamin E supplementation. The haptoglobin 2-2 polymorphism is associated with increased production of oxygen free radicals and reduces levels of vitamin E and C; the consequent elevated risk for cardiovascular disease can be prevented by vitamin E supplementation.

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