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Hepatology. 2008 Aug;48(2):670-8. doi: 10.1002/hep.22399.

Beyond insulin resistance: Innate immunity in nonalcoholic steatohepatitis.

Author information

1
Department of Medicine, University of California, San Francisco, CA, USA. jmaher@medsfgh.ucsf.edu

Abstract

Obesity is an inflammatory disorder characterized by heightened activity of the innate immune system. Innate immune activation is central to the development of obesity-related insulin resistance; it also plays an important role in obesity-related tissue damage, such as that seen in atherosclerosis. Recent research has implicated the innate immune system in the pathophysiology of obesity-related liver disease. This review summarizes how innate immune processes, occurring both within and outside the liver, cause not only insulin resistance but also end-organ damage in the form of nonalcoholic fatty liver disease.

PMID:
18666225
PMCID:
PMC3592568
DOI:
10.1002/hep.22399
[Indexed for MEDLINE]
Free PMC Article
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