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Drug Dev Ind Pharm. 2008 Dec;34(12):1394-405. doi: 10.1080/03639040802130061 .

Lipid nanoparticles with a solid matrix (SLN, NLC, LDC) for oral drug delivery.

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1
Laboratory of Pharmaceutical Technology and Biopharmacy, Universite Henri Poincare Nancy I, Nancy, France.

Abstract

Solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), and lipid-drug conjugates (LDC), commonly produced by high-pressure homogenization, are interesting vectors for oral delivery of lipophilic and, to a certain extent, hydrophilic substances. Their production can be done without the use of organic solvents. Techniques to make them a physically stable delivery system have been developed. Scaling up of the production process from lab-size to large-scale dimensions using high-pressure homogenization can be easily achieved by using a different type of homogenizer. The machines used for large-scale production often yield an even better product quality than the lab-scale types. This review article covers the methods of production, characterization, mechanisms of oral bioavailability enhancement, scale-up, final oral dosage forms, and regulatory aspects of lipid nanoparticles for oral drug delivery. It focuses mainly on high-pressure homogenization production methods.

PMID:
18665980
DOI:
10.1080/03639040802130061
[Indexed for MEDLINE]

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