Format

Send to

Choose Destination
J Clin Endocrinol Metab. 2008 Oct;93(10):3870-7. doi: 10.1210/jc.2008-0021. Epub 2008 Jul 29.

Correlates of low testosterone and symptomatic androgen deficiency in a population-based sample.

Author information

1
New England Research Institutes, Watertown, Massachusetts 02472, USA. shall@neriscience.com

Abstract

CONTEXT:

Risk factors for low testosterone and symptomatic androgen deficiency (AD) may be modifiable.

OBJECTIVE:

Our objective was to examine demographic, anthropometric, and medical correlates of low testosterone and symptomatic AD.

DESIGN:

Data were used from the Boston Area Community Health Survey, an epidemiological study conducted from 2002-2005.

SETTING:

Data were obtained from a community-based random sample of racially and ethnically diverse men.

PATIENTS OR OTHER PARTICIPANTS:

Data were available for 1822 men.

MAIN OUTCOME MEASURES:

Multivariate logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for associations of covariates with 1) low testosterone and 2) symptomatic AD. The operational definition of low testosterone was serum total testosterone less than 300 ng/dl and free testosterone less than 5 ng/dl; symptomatic AD was defined as the additional presence of symptoms: any of low libido, erectile dysfunction, or osteoporosis or two or more of sleep disturbance, depressed mood, lethargy, or diminished physical performance.

RESULTS:

Factors associated with low testosterone included age (OR = 1.36; 95% CI= 1.11-1.66, per decade), low per-capita income ($6000 or less per household member vs. more than $30,000; OR = 2.86; 95% CI = 1.39-5.87), and waist circumference (per 10-cm increase; OR = 1.75; 95% CI = 1.45-2.12). Only age (OR = 1.36; 95% CI = 1.04-1.77), waist circumference (OR = 1.88; 95% CI = 1.44-2.47), and health status (OR = 0.21; 95% CI = 0.05-0.92, excellent vs. fair/poor) were associated with our construct of symptomatic AD. Of all variables, waist circumference was the most important contributor in both models.

CONCLUSIONS:

Waist circumference is a potentially modifiable risk factor for low testosterone and symptomatic AD. Manifestation of symptoms may be a consequence of generally poor health status.

PMID:
18664536
PMCID:
PMC2579652
DOI:
10.1210/jc.2008-0021
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center