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Fitoterapia. 2008 Dec;79(7-8):598-601. doi: 10.1016/j.fitote.2008.06.007. Epub 2008 Jul 11.

Cytotoxic activity screening of some indigenous Thai plants.

Author information

1
Graduate School and Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand.

Abstract

The 50% ethanolic extracts from 14 plant species used in Thai traditional folklore were screened for cytotoxic activity against a malignant human hepatoma (HepG2) cell line and a normal African green monkey kidney (Vero) cell line. The extracts of Polyalthia evecta and Erythroxylum cuneatum showed potent anticancer activity in the HepG2 cell line with IC(50) of 70+/-3 microg/ml and 64+/-4 microg/ml, respectively. P. evecta demonstrated more selectivity to the HepG2 than the Vero cell (selectivity index>14.3) indicating its potential for biopharmaceutical use.

PMID:
18664377
DOI:
10.1016/j.fitote.2008.06.007
[Indexed for MEDLINE]

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