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Nat Prod Rep. 2008 Aug;25(4):757-93. doi: 10.1039/b801747f. Epub 2008 May 23.

Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways.

Author information

1
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115, USA.

Abstract

This review surveys efforts to reconstitute key steps in polyketide and nonribosomal peptide biosynthetic pathways with purified enzymes and substrates; 344 references are cited.

PMID:
18663394
DOI:
10.1039/b801747f
[Indexed for MEDLINE]

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